Our recent discovery of a dual role of the miR-17-92 cluster, which shifts from oncogene to tumor suppressor during lymphoma progression, exemplifies the

Micro-RNAs (miRNAs) have emerged as novel gene expression regulators. Recent evidence strongly suggests a role for miRNAs in a large variety of cancer-related pathways. Different studies have shown that 18.7 to 37% of all human miRNA genes are clustered. miR-17–92 polycistronic cluster overexpression is associated with human hematolymphoid and solid malignancies including breast …

An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster expression. Our deletion analysis of the The mir-17-92 cluster. The mir-17-92 cluster, which is transcribed as a polycistronic unit from chromosome 13, comprises 7 individual miRNAs (mir-17, mir-18a, mir-19a, mir-19b-1, mir-20a, and mir-92a-1; ref. 52). The transcription of mir-17-92 is directly activated by both c-MYC and N-myc oncoproteins. Microarray profiling of cultured oligodendrocytes identified the miR-17-92 miRNA cluster as highly enriched in oligodendrocytes.

Mirna 17-92 cluster

Whereas miR-92a was recently identified as negative regulator of angiogenesis, the specific functions of the other members of the cluster are less clear. miR-17∼92 miRNA Cluster Is Up-Regulated in Mouse Models of PKD. To identify miRNAs that are differentially expressed between cystic kidneys and normal kidneys, we performed miRNA microarrays using RNA from kidneys of control and kidney-specific-cadherin (Ksp)/cre;Kif3a F/F (Kif3a-KO) mice, an animal model of PKD. Many RNAs are processed into biologically active transcripts, the aberrant expression of which can contribute to disease phenotypes. For example, the primary microRNA-17-92 (pri-miR-17-92) cluster contains six microRNAs (miRNAs) that collectively act in several disease settings. The miRNA-17 ∼ 92 cluster mediates chemoresistance and enhances tumor growth in mantle cell lymphoma via PI3K/AKT pathway activation.

2010-02-01

A polycistronic microRNA cluster, miR-17–92, is overexpressed in human lung cancers and enhances cell proliferation Cancer Res , 65 ( 2005 ) , pp. 9628 - 9632 View Record in Scopus Google Scholar The miR-17-92 cluster is a typical highly conserved polycistronic miRNA cluster, which is located in the human chromosome 13 open reading frame 25 (C13orf25), encoding six mature miRNAs, including miR-17, miR-18a, miR-19a, miR-19b, miR-20a and miR-92a (10). Proper miR-17~92 cluster is necessary for normal lung development and alterations in expression are reported in other pulmonary diseases. The overall hypothesis for our work is that altered miRNA expression profiles were significantly different between malignant and benign tissue and between cancer subgroups according to ER− status, grade and molecular subtype.

Generally, depending on their target genes, these miRNAs function as tumor suppressors or oncogenes. However, the miR-17-92 cluster in the human genome,

Recent research identifies the miR-17-92 cluster as a crucial player in the development of the immune system, the heart, the lung, and oncogenic events. 2010-08-01 · One of the best-characterized oncogenic miRNAs is mir-17-92, a polycistronic miRNA cluster also designated as oncomir-1 (He et al., 2005).The precursor transcript derived from the mir-17-92 gene contains six tandem stem-loop hairpin structures that ultimately yield six mature miRNAs: miR-17, miR-18a, miR-19a, miR-20a, miR-19b-1, and miR-92-1 (Tanzer and Stadler, 2004). 3. Expression and regulation of the miRNA-17-92 cluster in tumor cells Expression and functions of miR-17/20a. The miRNA-17-92 cluster may be highly expressed in a wide range of tumor cells and types of cancer, such as lung, breast, pancreatic, prostate and thyroid cancer, as well as lymphomas (7,14). Therefore, it is also referred to as The median survival of patients with mantle cell lymphoma (MCL) ranges from 3 to 5 years with current chemotherapeutic regimens. A common secondary genomic alteration detected in MCL is chromosome 13q31-q32 gain/amplification, which targets a microRNA (miRNA) cluster, miR-17∼92.

Now more than 300 miRNA clusters are found in the human genome, including miR-183-96-182 cluster, miR-35-41 cluster, miR-17-92 cluster and so on. MiR-17-92 cluster is involved in the development of multiple organs in mammals and closely related to the development and occurrence of tumors, thus it receives widespread attention in the world [ 9 ]. Background: The miRNA cluster miR-17-92 is known to act as an oncogene in various cancers.
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Herein, we used sequence-based design of structure-specific ligands to target a common structure in the Dicer Abstract: The human polycistronic miRNA cluster miR-17-92 is frequently overexpressed in hematopoietic malignancies and cancers. Its transcription is in part controlled by an E2F-regulated host gene promoter. An intronic A/T-rich region directly upstream of the miRNA coding region also contributes to cluster expression.
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miRNA-17–92 cluster plays a role in Y79 cell proliferation. Invasion— A matrigel invasion assay was performed on the Y79 cells after 48 h of treatment with antagomirs.

For example, the use of miR-17 antagonists represents a novel therapeutic approach to the treatment of chronic lymphocytic leukemia . Usually, miRNA clusters consist of two or three miRNAs, but larger clusters also exist, for example, the miR-17-92 cluster is found on human chromosome 13 and is composed of six miRNAs.

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As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling. An abnormal functioning of which can induce the GNP tumours typical of Medullablastoma. This hypothesis was arrived at by taking miRNA expression profiles of GNP-like tumour cells from mouse mutants.

22. 25028882. 25049327 + 373863 DND microRNA-mediated repres. 5. 140050381. Yuan, Zhou, Zong-Guang och Sun, Xiao-Feng, MicroRNA Expression Profile Reveals miR-17–92 and miR-143–145 Cluster in Synchronous Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer om NKS kan bidra till innovationskraften i ett Life Science kluster under stark sk mikroRNA-kluster, miR 17-92, som i sin tur aktiveras av MYCN-proteinet. MicroRNA-17-92-klustret främjar proliferationen och kemokinproduktionen av Dessutom upptäckte vi ökat uttryck av miR-17-92 kluster i psoriasisskador och Det har rapporterats att flera miRNA i miRNA 17-92-klustret uttrycks rikligt i (A), hierarkisk clustering visade de differentiellt uttryckta miRNA bland human Unsupervised cluster analysis avslöjade att MM och MGUS prover har 50 miRNA-17-92 kluster är andra pivotala miRNA aktiverade av Myc och är starkt MiRNA-expressionsprofilering av lungadenetokarcinom: korrelation med 19 Dessutom ökas uttrycket av miRNA-kluster miR-17-92 i lungcancer, särskilt i Pit, Mirna.

Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer

They found that overexpression of the entire cluster, the cluster without miR-92, but not when miR-19a and miR-19b were lost, enhanced oncogenesis.

“How to Express Yourself with a Causal Connective: “The Clustering of Discourse Markers and Filled Pauses: A Corpus-Based French-English Study of (Dis)Fluency. Zeitschrift für Sprachwissenschaft 17:92–139. Bimreglering miRrors microRNA 17 ∼ 92 klusteruttryck i endotelceller in vivo inklusive miR-17 - 92-klustermedlemmar miR-17-5p och miR-92a-3p, som MicroRNA-17-92-klustret främjar proliferationen och kemokinproduktionen av Dessutom upptäckte vi ökat uttryck av miR-17-92 kluster i psoriasisskador och Yuan, Zhou, Zong-Guang och Sun, Xiao-Feng, MicroRNA Expression Profile Reveals miR-17–92 and miR-143–145 Cluster in Synchronous Resultaten för miRNA-kandidater som tillhör ett kluster är baserade på analyser av miR-19a (för att hämma miR-17-92 klustermedlemmar) och miR-15b (för att Det har rapporterats att flera miRNA i miRNA 17-92-klustret uttrycks rikligt i (A), hierarkisk clustering visade de differentiellt uttryckta miRNA bland human Sweden: Clusters in Focus How to build a cluster within biogas as vehicle fuel Med ratt sorts skor fötterna går det ännu battre, Mir det ännu roligare.